• AntiVirus & Security
• AVG Antivirus (free for home use!)
• KeyPass (store passwords securely)
• Browsers
• Chrome (from Google)
• Firefox
• Safari (from Apple)
• Developer Tools
• CodeSmith (code generator)
• IIS (Microsoft's web server)
• SQL Server 2008 
• Visual Stuio 2008
• Graphic Applications
• Adobe Photoshop
• PhotoScape
• Internet Software
• Filezilla FTP
• UTorrent
• Players/Viewers/Recorders
• Adobe Acrobat Reader
• Camtasia
• Flash Player
• VLC Media Player
• YouTube Downloader
• Productivity
• Micosoft Office (Outlook, Word, Excel, etc.)
• System Utilities
• Beyond Compare (file and folder comparison)
• Mozy Backup (www.mozy.com)
• Snag-It (screen capturing utility)
• Super Flexible File Synchronizer (sync your files - amazing!)
• WinDirStat (find out where all your free hard drive space went)
• WinRar (file compression utility)

...and let's not forget about all the patches and updates from Microsoft for Vista!

I'll be updating this as I think of and install more programs. What are some of the required programs you install?